Article

Evolution and inhibition of the FIKK effector kinase family in <i>P. falciparum</i>

2024-02-23

Abstract excerpt

Among the ∼200 Plasmodium species that infect vertebrates, six infect humans. Of these, P. falciparum causes >95% of all ∼500,000 annual fatalities. Phylogenetically, P. falciparum belongs to the Laverania subgenus, a group of Plasmodium species that infect great apes. Common to Laverania species is the family of FIKK kinases. One million years ago, a single FIKK kinase conserved in all Plasmodium species g...

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Literature Corpus work: f609fc5b-0efa-5969-99d0-745379a19f91
DOI: 10.1101/2024.02.22.581535

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