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Article

Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival.

Nature communications - 23 Feb 2021

Baker N, Catta-Preta C M C, Neish R, Sadlova J, Powell B, Alves-Ferreira E V C, Geoghegan V, Carnielli J B T, Newling K, Hughes C, Vojtkova B, Anand J, Mihut A, Walrad P B, Wilson L G, Pitchford J W, Volf P, Mottram J C

Abstract excerpt

Differentiation between distinct stages is fundamental for the life cycle of intracellular protozoan parasites and for transmission between hosts, requiring stringent spatial and temporal regulation. Here, we apply kinome-wide gene deletion and gene tagging in Leishmania mexicana promastigotes to define protein kinases with life cycle transition roles. Whilst 162 are dispensable, 44 protein kinase genes are...

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Identifiers

PMID: 33623024
DOI: 10.1038/s41467-021-21360-8
PMCID: PMC7902614

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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