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Phosphoproteomic Analysis of Differentiating <i>Leishmania</i> Parasites Reveals a Unique Stage-Specific Phosphorylation Motif

21 May 2013

Abstract excerpt

Protists of the genus Leishmania are obligatory intracellular parasites that cause a wide range of cutaneous, mucocutaneous, and visceral diseases in humans. They cycle between phagolysosomes of mammalian macrophages and the sand fly midgut, proliferating as intracellular amastigotes and extracellular promastigotes, respectively. Exposure to a lysosomal environment, i.e. acidic pH and body temperature, signals...

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PMID: 23688256
DOI: 10.1021/pr4002492

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