Article

Host kinase regulation of <i>Plasmodium vivax</i> dormant and replicating liver stages

2023-11-13

Abstract excerpt

Upon transmission to the liver, Plasmodium vivax parasites form replicating schizonts, which continue to initiate blood-stage infection, or dormant hypnozoites that reactivate weeks to months after initial infection. P. vivax phenotypes in the field vary significantly, including the ratio of schizonts to hypnozoites formed and the frequency and timing of relapse. Evidence suggests that both parasite genetics and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f72bddf5-afbe-5e73-976b-79e307a4b7b3
DOI: 10.1101/2023.11.13.566868

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Host kinase regulation of <i>Plasmodium vivax</i> dormant and replicating liver stagesDOI 10.1101/2023.11.13.566868Read

Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profilesSemantic proximity Read

The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compoundSemantic proximity Read

Signalome-wide assessment of erythrocyte response to <i>Plasmodium</i> reveals novel targets for host-directed antimalarial interventionSemantic proximity Read

Parasite and host kinases as targets for antimalarialsSemantic proximity Read

Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiensSemantic proximity Read

Evolution and inhibition of the FIKK effector kinase family in <i>P. falciparum</i>Semantic proximity Read

Gene signatures and host-parasite interactions revealed by dual single-cell profiling of <i>Plasmodium vivax</i> liver infectionSemantic proximity Read

Single-cell RNA profiling of <i>Plasmodium vivax</i> -infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targetsSemantic proximity Read

A single-cell liver atlas of Plasmodium vivax infectionSemantic proximity Read

Antimalarial drug discovery: targeting protein kinasesSemantic proximity Read

Using machine learning to dissect host kinases required for <i>Leishmania</i> internalization and developmentSemantic proximity Read

Network analysis of large phospho-signalling datasets: application to Plasmodium-erythrocyte interactionsSemantic proximity Read