Article

A genome-wide CRISPR screen defines host determinants of early <i>Brucella</i> infection in human macrophage-like cells

2026-05-19

Abstract excerpt

Brucella spp. are widespread intracellular animal pathogens that cause brucellosis, a significant zoonosis. Despite the global impact of brucellosis on animal and human health, the host genes that support Brucella infection remain incompletely defined. To address this knowledge gap, we developed a flow cytometry-based infection assay with fluorescent Brucella and performed a genome-wide CRISPR-Cas9 loss-of-funct...

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Literature Corpus work: 97beae54-501a-507b-bd59-b8fc29b5afde
DOI: 10.64898/2026.05.18.725962

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