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Article

Frontotemporal dementia associated CHCHD10V57E mutation aggravates tau pathology via disrupting the CHCHD10-Rab7A-TBC1D15 complex.

Cell death & disease - 19 Jun 2026

Sheng Jie, Yan Jing, Xu Yan, Xu Xingyu, Zhang Xuemei, Wang Anqi, Liu Buhui, Ma Jun, Duan Xiuying, Zhou Heng, Liu Wei

Abstract excerpt

Frontotemporal dementia (FTD), a neurodegenerative disorder characterized by early-onset cognitive decline, includes two major pathologic types: FTD-Tau and FTD-TDP. Coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10) encodes a mitochondrial protein, and the CHCHD10V57E variant is a novel mutation clinically identified in FTD patients. The role of CHCHD10 mutants in the pathogenesis of FTD-TDP has...

Read the complete abstract on PubMed

Topics

Animals
Frontotemporal Dementia
Humans
tau Proteins
Mitochondrial Proteins
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

rab GTP-Binding Proteins

rab7 GTP-Binding Proteins

Drosophila melanogaster

Drosophila Proteins

Mitochondria

Source

Open in PubMed Open full text

Identifiers

PMID: 42321182
DOI: 10.1038/s41419-026-08983-9
PMCID: PMC13526787

Genes

CHCHD10
TBC1D15

Variants

Provenance

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