Article

Dynein Light Chain LC8 Alleviates Nonalcoholic Steatohepatitis By Regulating Nuclear Factor κB Through Interference With IκBα Phosphorylation

2021-09-30

Abstract excerpt

<title>Abstract</title> <p>Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by fat accumulation and chronic inflammation in the liver. Although dynein light chain of 8 kDa (LC8) was identified previously as an inhibitor of nuclear factor kappa B (NF-κB), a key regulator of inflammation, its role in NASH remains unknown. In this study, we investigated whether LC8 can alleviate NASH using a mous...

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Literature Corpus work: c26e19cd-ce93-5dc7-bbda-5c0b9c6caa65
DOI: 10.21203/rs.3.rs-906706/v1

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