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Metronidazole enhances steatosis-related early-stage hepatocarcinogenesis in high fat diet-fed rats through DNA double-strand breaks and modulation of autophagy

2021-03-11

Abstract excerpt

<title>Abstract</title> <p>Nonalcoholic fatty liver disease is a hepatic disorder with deposition of fat droplets, and has a high risk of progression to steatosis-related hepatitis and irreversible hepatic cancer. Metronidazole (MNZ) is an antiprotozoal and antimicrobial agent widely used to treat patients infected with anaerobic bacteria and intestinal parasites; however, MNZ has also been shown to induce liver...

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Literature Corpus work
5fbb4ce8-e725-53fb-b960-37a7fd7f2a1e
DOI
10.21203/rs.3.rs-160304/v1
Open publication

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Metronidazole enhances steatosis-related early-stage hepatocarcinogenesis in high fat diet-fed rats through DNA double-strand breaks and modulation of autophagyDOI 10.21203/rs.3.rs-160304/v1
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