Article

Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2

2023-03-29

Abstract excerpt

Hydroxycarboxylic acid receptor 2 (HCAR2) belongs to the family of class A G-protein-coupled receptors with key roles in regulating lipolysis and free fatty acid formation in humans. It is deeply involved in many pathophysiological processes and serves as an attractive target for the treatment of neoplastic, autoimmune, neurodegenerative, inflammatory, and metabolic diseases. Here, we report four cryo-EM structure...

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Literature Corpus work: c266b7d0-54da-5280-aed6-76811917058c
DOI: 10.1101/2023.03.28.534513

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