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Article

Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation.

Chemistry & biology - 24 Nov 2008

Pei Ying, Mercier Richard W, Anday Jenine K, Thakur Ganesh A, Zvonok Alexander M, Hurst Dow, Reggio Patricia H, Janero David R, Makriyannis Alexandros

Abstract excerpt

The extensive physiological influence of transmission through the CB2 cannabinoid receptor makes this G protein-coupled receptor (GPCR) a promising therapeutic target for treating neuropathic pain, inflammation, and immune disorders. However, there is little direct structural information pertaining to either GPCR or CB2-receptor ligand recognition and activation. The present work helps characterize experimentally...

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Identifiers

PMID: 19022181
DOI: 10.1016/j.chembiol.2008.10.011
PMCID: PMC3700404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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