Article

Tumor-secreted versican co-opts myeloid IKKβ during metastasis

2021-05-22

Abstract excerpt

The mechanisms tumor cells use to hijack the immune system are largely uncharted. Here we used bioluminescent nuclear factor (NF)-κB reporter mice and macrophages to discover that metastatic tumors trigger NF-κB activation in host macrophages, dependent on mutant KRAS signaling and delivered via secretory versican. Versican activates NF-κB in tumor-associated macrophages via inhibitor of NF-κB kinase (IKK) β, res...

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Literature Corpus work: c230ae8d-ff39-5e60-95ee-6b070b2ec79e
DOI: 10.1101/2021.05.20.444963

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