Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion.

doi:10.1038/s41467-018-03051-z

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion.

Nature communications - 14 Feb 2018

Marazioti Antonia, Lilis Ioannis, Vreka Malamati, Apostolopoulou Hara, Kalogeropoulou Argyro, Giopanou Ioanna, Giotopoulou Georgia A, Krontira Anthi C, Iliopoulou Marianthi, Kanellakis Nikolaos I, Agalioti Theodora, Giannou Anastasios D, Jones-Paris Celestial, Iwakura Yoichiro, Kardamakis Dimitrios, Blackwell Timothy S, Taraviras Stavros, Spella Magda, Stathopoulos Georgios T

Abstract excerpt

Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers. While we previously identified KRAS mutations as molecular culprits of MPE formation, the underlying mechanism remained unknown. Here, we determine that non-canonical IKKα-RelB pathway activation of KRAS-mutant tumor cells mediates MPE development and this is fueled by host-provided interleukin IL-1β. Indeed, IKKα is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine CXCL1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to I-kappa B Kinase

Share to Interleukin-1beta

Share to Myeloid Cells

Share to NF-kappa B

Share to Pleural Effusion, Malignant

Share to Receptors, Interleukin-1

Source

Open in PubMed Open full text

Identifiers

PMID: 29445180
DOI: 10.1038/s41467-018-03051-z
PMCID: PMC5813197

Genes

KRAS
CXCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion.PMID 29445180Read ↗

IKK is a therapeutic target in KRAS-induced lung cancer with disrupted p53 activitySemantic proximity Read ↗

Immune modulatory effects of oncogenic KRAS in cancerSemantic proximity Read ↗

Tumor-secreted versican co-opts myeloid IKKβ during metastasisSemantic proximity Read ↗

IKKβ Kinase Promotes Stemness, Migration, and Invasion in KRAS-Driven Lung Adenocarcinoma Cells.Semantic proximity Read ↗

KRAS signalling in malignant pleural mesotheliomaSemantic proximity Read ↗

Type I interferon signaling pathway enhances immune-checkpoint inhibition in KRAS mutant lung tumors.Semantic proximity Read ↗

Pulmonary Inflammation and KRAS Mutation in Lung Cancer.Semantic proximity Read ↗

MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors.Semantic proximity Read ↗

Attribution of NF-κB Activity to CHUK/IKKα-Involved CarcinogenesisSemantic proximity Read ↗

Concurrent PIK3CA mutant drives cachexia through inflammatory signaling in EGFR mutant lung cancerSemantic proximity Read ↗

KRAS signaling in malignant pleural mesotheliomaSemantic proximity Read ↗

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.