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Identification of VISTA regulators in macrophages mediating cancer cell survival

27 Nov 2024

Abstract excerpt

Numerous human cancers have exhibited the ability to elude immune checkpoint blockade (ICB) therapies. This type of resistance can be mediated by immune-suppressive macrophages that limit antitumor immunity in the tumor microenvironment (TME). Here, we elucidate a strategy to shift macrophages into a proinflammatory state that down-regulates V domain immunoglobulin suppressor of T cell activation (VISTA) via...

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Cancer Immunotherapy and Biomarkers
Immune Cell Function and Interaction
Immune cells in cancer

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39602545
DOI: 10.1126/sciadv.adq8122

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