Article

A novel vimentin variant from tumor-associated macrophages directs cancer metastasis by engaging IGF-1R

2025-02-27

Abstract excerpt

<h4>SUMMARY</h4> Tumor-associated macrophages (TAMs) are recognized for their role in promoting malignancy. However, the specific mechanisms by which they drive cancer cell migration remain largely unexplored. Here, we identified a novel N-terminal-less variant of vimentin, a cytoskeletal intermediate filament protein, that is selectively secreted by TAMs through a type I unconventional secretion pathway followin...

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Literature Corpus work: de7ebc29-fc42-5551-988b-ee14759294fd
DOI: 10.1101/2025.02.27.640678

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