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Article

Dickkopf1 fuels inflammatory cytokine responses

20 Dec 2022

Abstract excerpt

Many human diseases, including cancer, share an inflammatory component but the molecular underpinnings remain incompletely understood. We report that physiological and pathological Dickkopf1 (DKK1) activity fuels inflammatory cytokine responses in cell models, mice and humans. DKK1 maintains the elevated inflammatory tone of cancer cells and is required for mounting cytokine responses following ligation of...

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PMID: 36539532
DOI: 10.1038/s42003-022-04368-8

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