Article
Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy.
Oncotarget - 15 Oct 2014
Donnard Elisa, Asprino Paula F, Correa Bruna R, Bettoni Fabiana, Koyama Fernanda C, Navarro Fabio C P, Perez Rodrigo O, Mariadason John, Sieber Oliver M, Strausberg Robert L, Simpson Andrew J G, Jardim Denis L F, Reis Luiz Fernando L, Parmigiani Raphael B, Galante Pedro A F, Camargo Anamaria A
Abstract excerpt
We carried out a mutational analysis of 3,594 genes coding for cell surface proteins (Surfaceome) in 23 colorectal cancer cell lines, searching for new altered pathways, druggable mutations and mutated epitopes for targeted therapy in colorectal cancer. A total of 3,944 somatic non-synonymous substitutions and 595 InDels, occurring in 2,061 (57%) Surfaceome genes were catalogued. We identified 48 genes not...
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