Article
Drug targeting to sites of oxidative stress using the Baeyer-Villiger reaction
2021-09-06
Abstract excerpt
The antioxidant nuclear factor erythroid 2-related factor 2 (Nrf2) is a desirable therapeutic target for a broad range of pathologies, including chronic diseases of the lung and liver, and autoimmune, neurodegenerative, and cardiovascular disorders. However, current Nrf2 activators are limited by unwanted effects due to non-specificity, and systemic distribution and action. Here we report that a 1,2-dicarbonyl moi...
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Identifiers and source
- Literature Corpus work
- c225d6c4-724a-544d-b79c-b99359510ca8
- DOI
- 10.1101/2021.09.03.458872