Targeting Alzheimer's disease hallmarks with the Nrf2 activator Isoeugenol

Abstract excerpt

Alzheimer´s disease is a neurodegenerative disease and the most common cause of dementia with no cure or treatment. Therefore, the investigation to find a disease-modifying therapeutic is crucial. From a pathophysiological point of view, AD is characterized by the loss of homeostatic functions that control redox and energy metabolism, neuroinflammation, and proteostasis. The transcription factor nuclear factor ery...

Topics

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• Amyloid beta-Protein Precursor
• Antioxidants
• Cognition
• Genomics, phytochemicals, and oxidative stress
• Inflammation
• NF-E2-Related Factor 2
• Oxidative Stress
• Proteasome Endopeptidase Complex

Identifiers and source

Literature Corpus work

1010b278-c4c8-5779-ba23-6e1ed6c85e31

DOI

10.32388/luxm7w