Article
Investigation of Nrf2 activity measures for assessing the toxicological and pharmacological effects of drugs
2018-01-01
Abstract excerpt
The transcription factor Nuclear factor erythroid 2-related factor 2 (NRF2) orchestrates the expression of a battery of cytoprotective genes containing antioxidant response elements (AREs) within their promotersequences. Activation of the NRF2 pathway has been implicated in the early stages of drug-induced toxicity, a major cause of drug attrition and public risk, and therefore holds potential as a pre-clinical ma...
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Identifiers and source
- Literature Corpus work
- 998e00a1-b129-5074-9512-f3550e68a8a2
- DOI
- 10.17638/03022492