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The Emerging Role of Dimethyl Fumarate in Alzheimer’s Disease—A Systematic Review of Available Preclinical Studies

2026-03-31

Abstract excerpt

Dimethyl fumarate (DMF), a fumaric acid ester, is approved for psoriasis and multiple sclerosis due to its antioxidant and anti-inflammatory properties mediated via Nrf2 activation. Nrf2 regulates genes that protect cells from oxidative stress, a key factor in neurodegenerative diseases such as Alzheimer's disease (AD), which is characterized by amyloid-β and tau accumulation and lipid peroxidation. This syst...

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Literature Corpus work
0eb575d1-5039-5b4c-8e07-3b7395706805
DOI
10.20944/preprints202603.2414.v1
Open publication

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The Emerging Role of Dimethyl Fumarate in Alzheimer’s Disease—A Systematic Review of Available Preclinical StudiesDOI 10.20944/preprints202603.2414.v1
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