Article

Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH

2024-04-26

Abstract excerpt

Heme is an iron-containing cofactor essential for life. In eukaryotes heme is generated in the mitochondria and must leave this organelle to reach protein targets in other cell compartments. Mitochondrial heme binding by cytosolic GAPDH was recently found essential for heme distribution in eukaryotic cells. Here, we sought to uncover how mitochondrial heme reaches GAPDH. Experiments involving a human cell line and...

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Identifiers and source

Literature Corpus work: c2245453-a93a-51cd-8def-ff1c3405bf2d
DOI: 10.1101/2024.04.23.590782

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