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Article

Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.

The Journal of biological chemistry - 16 May 2008

Trapasso Francesco, Pichiorri Flavia, Gaspari Marco, Palumbo Tiziana, Aqeilan Rami I, Gaudio Eugenio, Okumura Hiroshi, Iuliano Rodolfo, Di Leva Giampiero, Fabbri Muller, Birk David E, Raso Cinzia, Green-Church Kari, Spagnoli Luigi G, Venuta Salvatore, Huebner Kay, Croce Carlo M

Abstract excerpt

Fhit protein is lost in most cancers, its restoration suppresses tumorigenicity, and virus-mediated FHIT gene therapy induces apoptosis and suppresses tumors in preclinical models. We have used protein cross-linking and proteomics methods to characterize a Fhit protein complex involved in trigger...

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Identifiers

PMID: 18319262
DOI: 10.1074/jbc.M709062200
PMCID: PMC2376222

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18319262-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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