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Article

GAPDH regulates cellular heme insertion into inducible nitric oxide synthase.

Proceedings of the National Academy of Sciences of the United States of America - 19 Oct 2010

Chakravarti Ritu, Aulak Kulwant S, Fox Paul L, Stuehr Dennis J

Abstract excerpt

Heme proteins play essential roles in biology, but little is known about heme transport inside mammalian cells or how heme is inserted into soluble proteins. We recently found that nitric oxide (NO) blocks cells from inserting heme into several proteins, including cytochrome P450s, hemoglobin, NO synthases, and catalase. This finding led us to explore the basis for NO inhibition and to identify cytosolic proteins...

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Identifiers

PMID: 20921417
DOI: 10.1073/pnas.1008133107
PMCID: PMC2964200

Genes

GAPDH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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