Article

Development of a Genetically Encoded Live-Cell Iron Mapping System

2025-02-27

Abstract excerpt

Any disturbances in cellular iron regulation can lead to dysfunctions and various diseases. However, our current understanding of iron dynamics in living cells is hampered by the lack of high-resolution iron reporter systems capable of monitoring the iron status of individual cells dynamically. To address this challenge, we have developed the Live-Cell Iron Mapping System (LIMS), which consists of two distinct gen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bdd7aba2-de24-5caf-8263-a5cae3eb7301
DOI: 10.1101/2025.02.25.639876

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of a Genetically Encoded Live-Cell Iron Mapping SystemDOI 10.1101/2025.02.25.639876Read

In vivo visualization of bioactive iron and oxygen using the Labile Iron and Oxygen Notifier (LiON)Semantic proximity Read

Optical Monitoring of In Situ Iron Loading into Single, Native Ferritin ProteinsSemantic proximity Read

Lights on iron-sulfur clusters.Semantic proximity Read

The role of iron regulatory proteins in mammalian iron homeostasis and disease.Semantic proximity Read

Ferroptosis resistance mediated by exosomal release of ironSemantic proximity Read

Iron TransportSemantic proximity Read

Mapping the genetic landscape of iron metabolism uncovers the SETD2 methyltransferase as a modulator of iron fluxSemantic proximity Read

Homeostatic Mechanisms for Iron Storage Revealed by Genetic Manipulations and Live Imaging of Drosophila FerritinSemantic proximity Read

A chiral fluorescent Ir( iii ) complex that targets the GPX4 and ErbB pathways to induce cellular ferroptosisSemantic proximity Read

Iron transport across biologic membranes.Semantic proximity Read

Ferritin nanoparticles as magnetic resonance reporter geneSemantic proximity Read

Visualizing Mitochondrial Heme Flow through GAPDH to Targets in Living Cells and its Regulation by NOSemantic proximity Read