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Article

TANGO2 is an acyl-CoA binding protein.

The Journal of cell biology - 5 May 2025

Lujan Agustin Leonardo, Foresti Ombretta, Wojnacki Jose, Bigliani Gonzalo, Brouwers Nathalie, Pena Maria Jesus, Androulaki Stefania, Hashidate-Yoshida Tomomi, Kalyukina Maria, Novoselov Sergey S, Shindou Hideo, Malhotra Vivek

Abstract excerpt

Loss of TANGO2 in humans precipitates metabolic crises during periods of heightened energy demand, such as fasting, infections, or high fever. TANGO2 has been implicated in various functions, including lipid metabolism and heme transport, and its cellular localization remains uncertain. In our study, we demonstrate that TANGO2 localizes to the mitochondrial lumen via a structural region containing LIL residues....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40015245
DOI: 10.1083/jcb.202410001
PMCID: PMC11867700

Genes

TANGO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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