Article

CLPX regulates erythroid heme synthesis by control of mitochondrial heme synthesis enzymes and iron utilization

2020-09-09

Abstract excerpt

Heme is a prosthetic group that plays a critical role in catalyzing life-essential redox reactions in all cells, including critical metabolic processes. Heme synthesis must be tightly co-regulated with cellular requirements in order to maximize utilization and minimize toxicity. Terminally differentiating erythroid cells have an extremely high demand for heme for hemoglobin synthesis. While the enzymatic reactions...

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Literature Corpus work: 5efea18c-60ad-5464-acdd-a82f9f357ee9
DOI: 10.1101/2020.09.09.289660

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