Article

Gelsolin Facilitates Estrogen Receptor Beta Nuclear Translocation and Transcriptional Repression of Genes Associated with Alzheimer Disease

2025-02-25

Abstract excerpt

<h4>Background: </h4> /Objectives: Gelsolin (GSN) is an actin-binding protein that helps maintain neuronal structure and shape, regulates neuronal growth, and apoptosis. Our previous work demonstrated that GSN associated with estrogen receptor beta (ERb1) in the brains of female rats, but this association was lost in advanced age. GSN was also required for ERb1-mediated transcriptional repression at activator prot...

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Literature Corpus work: c218c7eb-d6eb-50be-91e5-6d312b885b6d
DOI: 10.20944/preprints202502.1979.v1

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