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The human papillomavirus-16 E7 oncoprotein exerts antiapoptotic effects via its physical interaction with the actin-binding protein gelsolin.

Carcinogenesis - 1 Oct 2013

Mileo Anna M, Abbruzzese Claudia, Vico Carmen, Bellacchio Emanuele, Matarrese Paola, Ascione Barbara, Federico Antonio, Della Bianca Stefano, Mattarocci Stefano, Malorni Walter, Paggi Marco G

Abstract excerpt

The oncoprotein E7 from human papillomavirus-16 (HPV-16 E7) plays a pivotal role in HPV postinfective carcinogenesis, and its physical interaction with host cell targets is essential to its activity. We identified a novel cellular partner for the viral oncoprotein: the actin-binding protein gelso...

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PMID: 23729654
DOI: 10.1093/carcin/bgt192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23729654-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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