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Article

Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus--linking NMDA receptors and the reelin pathway.

Experimental neurology - 1 Nov 2014

Mota Sandra I, Ferreira Ildete L, Valero Jorge, Ferreiro Elisabete, Carvalho Ana L, Oliveira Catarina R, Rego A Cristina

Abstract excerpt

Early cognitive deficits in Alzheimer's disease (AD) have been related to deregulation of N-methyl-d-aspartate receptors (NMDARs) and synaptic dysfunction in response to amyloid-beta peptide. NMDAR anchorage to post-synaptic membrane depends in part on Src kinase, which is also implicated in NMDAR activation and actin cytoskeleton stabilization, two processes relevant for normal synaptic function. In this study...

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Share to Amyloid beta-Protein Precursor
Share to Cell Adhesion Molecules, Neuronal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Presenilin-1

Share to Receptors, N-Methyl-D-Aspartate

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Source

Identifiers

PMID: 25128699
DOI: 10.1016/j.expneurol.2014.07.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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