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Article

Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis.

The Journal of biological chemistry - 5 Apr 2002

Greenfield Jeffrey P, Leung Lawrence W, Cai Dongming, Kaasik Krista, Gross Rachel S, Rodriguez-Boulan Enrique, Greengard Paul, Xu Huaxi

Abstract excerpt

Estrogen reduces the risk of Alzheimer's disease in post-menopausal women, beta-amyloid (Abeta) burden in animal models of Alzheimer's disease, and secretion of Abeta from neuronal cultures. The biological basis for these effects remains unknown. Here, utilizing cell-free systems derived from both neuroblastoma cells and primary neurons, we demonstrate that 17beta-estradiol (17beta-E2) stimulates formation of...

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Identifiers

PMID: 11823458
DOI: 10.1074/jbc.M110009200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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