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Article

A nuclear actin function regulates neuronal motility by serum response factor-dependent gene transcription.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Apr 2009

Stern Sina, Debre Evaine, Stritt Christine, Berger Jürgen, Posern Guido, Knöll Bernd

Abstract excerpt

Neuronal motility relies on actin treadmilling. In addition to regulating cytoskeletal dynamics in the cytoplasm, actin modulates nuclear gene expression. We present a hitherto unappreciated cross talk of actin signaling with gene expression governing neuronal motility. Toward this end, we used a novel approach using mutant actins either favoring (G15S) or inhibiting (R62D) F-actin assembly. Overexpressing these...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19357276
DOI: 10.1523/JNEUROSCI.0333-09.2009
PMCID: PMC6665722

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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