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Article

Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis

7 Aug 2001

Abstract excerpt

The molecular mechanisms that regulate neuronal cell death in neurodegenerative diseases remain unclear. During neurologic diseases numerous neuronal and glial intracellular signaling pathways are activated by changes within the extracellular environment, which culminate in alterations of nuclear proteins and gene expression. Among the proteins activated or expressed during neurodegenerative diseases include...

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Identifiers

PMID: 12214040
DOI: 10.3233/jad-2001-3403

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