Article

Functional conservation and divergence of Arabidopsis VENOSA4 and human SAMHD1 in DNA repair

2024-05-31

Abstract excerpt

<h4>SUMMARY</h4> The human deoxyribonucleoside triphosphatase (dNTPase) Sterile alpha motif and histidine-aspartate domain containing protein 1 (SAMHD1) has a dNTPase-independent role in repairing DNA double-strand breaks (DSBs) by homologous recombination (HR). Here, we show that VENOSA4 (VEN4), the probable Arabidopsis thaliana ortholog of SAMHD1, also functions in DSB repair by HR. The ven4 loss-of-function...

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Literature Corpus work: c202ac65-9294-53da-bc72-0bc1d4f39235
DOI: 10.1101/2024.05.27.596045

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