Article

SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammation

2022-08-27

Abstract excerpt

<h4>ABSTRACT</h4> SAMHD1 is a key regulator of dNTP metabolism, being activated by dGTP and converting dNTPs into their respective nucleosides. As a result, it plays a significant role in several distinct diseases. Not only is SAMHD1 a restriction factor for HIV-1 replication, which requires dNTPs for replication, but it is also required for genome stability, is mutated in multiple cancers, and loss of function m...

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Identifiers and source

Literature Corpus work: 51237642-2505-5d17-b6ad-e2d749547ebf
DOI: 10.1101/2022.08.25.505278

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