Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SAMHD1 in cancer: curse or cure?

Journal of molecular medicine (Berlin, Germany) - 1 Mar 2022

Schott Kerstin, Majer Catharina, Bulashevska Alla, Childs Liam, Schmidt Mirko H H, Rajalingam Krishnaraj, Munder Markus, König Renate

Abstract excerpt

Human sterile α motif and HD domain-containing protein 1 (SAMHD1), originally described as the major cellular deoxyribonucleoside triphosphate triphosphohydrolase (dNTPase) balancing the intracellular deoxynucleotide (dNTP) pool, has come recently into focus of cancer research. As outlined in this review, SAMHD1 has been reported to be mutated in a variety of cancer types and the expression of SAMHD1 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Immunotherapy and Immune Responses

Share to Monomeric GTP-Binding Proteins

Share to Mutation

Share to Neoplasms

Share to SAM Domain and HD Domain-Containing Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 34480199
DOI: 10.1007/s00109-021-02131-w
PMCID: PMC8843919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SAMHD1 in cancer: curse or cure?PMID 34480199Read ↗

Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).Semantic proximity Read ↗

With me or against me: Tumor suppressor and drug resistance activities of SAMHD1.Semantic proximity Read ↗

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications.Semantic proximity Read ↗

SAMHD1 Functions and Human Diseases.Semantic proximity Read ↗

SAMHD1 acetylation enhances its deoxynucleotide triphosphohydrolase activity and promotes cancer cell proliferationSemantic proximity Read ↗

SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammationSemantic proximity Read ↗

SAMHD1 silencing cooperates with radiotherapy to enhance anti-tumor immunity through IFI16-STING pathway in lung adenocarcinomaSemantic proximity Read ↗

Identification of natural splice variants of SAMHD1 in virus-infected HCC.Semantic proximity Read ↗

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cellsSemantic proximity Read ↗

De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivitySemantic proximity Read ↗

Up-regulation of SAMHD1 gene construction of a prognosis biomarker for survival and prognostic in breast invasive carcinomaSemantic proximity Read ↗

De-ubiquitination of SAMHD1 by USP7 overcomes oncogenic stress and contributes to chemotherapy insensitivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.