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Article

SAMHD1 Functions and Human Diseases.

Viruses - 31 Mar 2020

Coggins Si'Ana A, Mahboubi Bijan, Schinazi Raymond F, Kim Baek

Abstract excerpt

Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and maintenance of genomic information in both cells and a variety of viral pathogens. While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been extensively investigated, a negative regulatory mechanism of dNTP pools was recently found to involve sterile...

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Source

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Identifiers

PMID: 32244340
DOI: 10.3390/v12040382
PMCID: PMC7232136

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