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Analysis of the Arabidopsis venosa4-0 mutant supports the role of VENOSA4 in dNTP metabolism.

Plant science : an international journal of experimental plant biology - 1 Oct 2023

Sarmiento-Mañús Raquel, Fontcuberta-Cervera Sara, González-Bayón Rebeca, Hannah Matthew A, Álvarez-Martínez Francisco Javier, Barrajón-Catalán Enrique, Micol Vicente, Quesada Víctor, Ponce María Rosa, Micol José Luis

Abstract excerpt

Human Sterile alpha motif and histidine-aspartate domain containing protein 1 (SAMHD1) functions as a dNTPase to maintain dNTP pool balance. In eukaryotes, the limiting step in de novo dNTP biosynthesis is catalyzed by RIBONUCLEOTIDE REDUCTASE (RNR). In Arabidopsis, the RNR1 subunit of RNR is encoded by CRINKLED LEAVES 8 (CLS8), and RNR2 by three paralogous genes, including TSO MEANING 'UGLY' IN CHINESE 2 (TSO2)....

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PMID: 37562732
DOI: 10.1016/j.plantsci.2023.111819

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