Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).

International journal of oncology - 1 Apr 2020

Zhang Zhou, Zheng Lixia, Yu Yang, Wu Jinying, Yang Fan, Xu Yingxi, Guo Qiqiang, Wu Xuan, Cao Sunrun, Cao Liu, Song Xiaoyu

Abstract excerpt

Sterile alpha motif and histidine/aspartic acid domain‑containing protein 1 (SAMHD1), the only deoxynucleotide triphosphate (dNTP) hydrolase in eukaryotes, plays a crucial role in regulating the dynamic balance and ratio of cellular dNTP pools. Furthermore, SAMHD1 has been reported to be involved in the pathological process of several diseases. Homozygous SAMHD1 mutations have been identified in immune system...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomic Instability

Share to Homeostasis

Share to Mutation

Share to Neoplasms

Share to SAM Domain and HD Domain-Containing Protein 1

Source

Identifiers

PMID: 32319570
DOI: 10.3892/ijo.2020.4988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).PMID 32319570Read ↗

SAMHD1 Functions and Human Diseases.Semantic proximity Read ↗

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications.Semantic proximity Read ↗

SAMHD1 in cancer: curse or cure?Semantic proximity Read ↗

Aicardi-Goutières Syndrome caused by SAMHD1 mutation: Pathogenesis and Beyond.Semantic proximity Read ↗

SAMHD1 acetylation enhances its deoxynucleotide triphosphohydrolase activity and promotes cancer cell proliferationSemantic proximity Read ↗

SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammationSemantic proximity Read ↗

SAMHD1-deficient fibroblasts from Aicardi-Goutières Syndrome patients can escape senescence and accumulate mutations.Semantic proximity Read ↗

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cellsSemantic proximity Read ↗

With me or against me: Tumor suppressor and drug resistance activities of SAMHD1.Semantic proximity Read ↗

SAMHD1 prevents autoimmunity by maintaining genome stabilitySemantic proximity Read ↗

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesSemantic proximity Read ↗

The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral ResponseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.