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<i>In vivo</i> generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearance

2025-04-24

Abstract excerpt

Despite striking efficacy against hematologic malignancies, the cost and complexity of CAR T manufacturing present significant barriers to broader patient access. Beyond manufacturing challenges, ex vivo expansion of T cells may be detrimental for their function and persistence. Thus, delivery of CARs to reprogram host cells in vivo would represent a significant advance toward “off-the-shelf” therapy but has bee...

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Literature Corpus work
c1e9c81e-73e8-5f22-a3c6-fe23296f5aeb
DOI
10.1101/2025.04.23.645810
Open publication

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<i>In vivo</i> generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearanceDOI 10.1101/2025.04.23.645810
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