Article

Targeting PD-1 <sup>+</sup> T-cells with Chimeric Antigen Receptors to reduce the HIV Reservoir

2025-09-16

Abstract excerpt

The unique ability of chimeric antigen receptor (CAR) T-cells to infiltrate tissues is revolutionizing our perspectives for tackling severe-refractory and otherwise untreatable diseases. In HIV, CAR-T-cells have been designed to target viral biomarkers, with limited success so far. Here, we investigated the possibility of redirecting CAR-T-cells against a cellular biomarker of the HIV reservoir, PD-1. We designed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3033c224-7001-57db-9f21-20457b5c8a90
DOI: 10.1101/2025.09.10.675382

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting PD-1 <sup>+</sup> T-cells with Chimeric Antigen Receptors to reduce the HIV ReservoirDOI 10.1101/2025.09.10.675382Read

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance anti-HIV activity in vitroSemantic proximity Read

Broadly neutralizing antibody-secreting CAR-T cells elicit Fc-mediated effector functions <i>in vitro</i> and suppress HIV in humanized miceSemantic proximity Read

Robust CAR-T memory formation and function via hematopoietic stem cell deliverySemantic proximity Read

HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing AntibodiesSemantic proximity Read

Stem cell–derived CAR T cells traffic to HIV reservoirs in macaquesSemantic proximity Read

Dynamic CD4+ T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection.Semantic proximity Read

Broadly neutralizing antibody–derived CAR T cells reduce viral reservoir in individuals infected with HIV-1Semantic proximity Read

<i>In vivo</i> generation of chimeric antigen receptor T cells using optimally retargeted and functionalized lentiviral vectors with reduced immune clearanceSemantic proximity Read

Differentiating PD-1+ stem-like CD8 T cells towards distinct effectors with enhanced therapeutic potential by an engineered IL-2 cis-targeted to PD-1Semantic proximity Read

Unlocking the potential of Tregs: innovations in CAR technologySemantic proximity Read

Chimeric Antigen Receptor Engineered Stem Cells: A Novel HIV TherapySemantic proximity Read

TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs <i>in vivo</i>Semantic proximity Read