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Cell type-specific delivery by modular envelope design

23 Aug 2023

Abstract excerpt

The delivery of genetic cargo remains one of the largest obstacles to the successful translation of experimental therapies, in large part due to the absence of targetable delivery vectors. Enveloped delivery modalities use viral envelope proteins, which determine tropism and induce membrane fusion. Here we develop DIRECTED (Delivery to Intended REcipient Cells Through Envelope Design), a modular platform that...

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PMID: 37612276
DOI: 10.1038/s41467-023-40788-8

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