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Progress in Pseudotyping Lentiviral Vectors Towards Cell-Specific Gene Delivery In Vivo

31 May 2025

Abstract excerpt

Lentiviral vectors (LVs) have become a fundamental tool in gene therapy due to their unique ability to transduce both dividing and non-dividing cells, transfer large genes of up to 10 kb, and facilitate stable, long-term expression of therapeutic genes into target cells. A key application of LVs is the ex vivo genetic modification of patient-derived cells, such as the production of CAR-T cells by transducing...

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PMID: 40573393
DOI: 10.3390/v17060802

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