Article

AA147 Alleviates Symptoms in a Mouse Model of Multiple Sclerosis by Reducing Oligodendrocyte Loss

2025-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Inflammation induced oligodendrocyte death and CNS demyelination, are key features of multiple sclerosis (MS). Inflammation-triggered endoplasmic reticulum (ER) stress and oxidative stress promote tissue damage in MS and in its preclinical animal model, experimental autoimmune encephalitis (EAE). Compound AA147 is a potent activator of the ATF6 signaling arm of the unfolded protein response (UPR...

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Literature Corpus work: c1d88381-dfae-5cba-9244-8ac04cb7f9e7
DOI: 10.1101/2025.01.01.630914

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