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Article

Neurodegeneration: Keeping ATF4 on a Tight Leash

15 Dec 2017

Abstract excerpt

Activation of the endoplasmic reticulum (ER) stress and ER stress response, also known as the unfolded protein response (UPR), is common to various degenerative disorders. Therefore, signaling components of the UPR are currently emerging as potential targets for intervention and treatment of human diseases. One UPR signaling member, activating transcription factor 4 (ATF4), has been found up-regulated in many...

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PMID: 29326555
DOI: 10.3389/fncel.2017.00410

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