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UPR Responsive Genes Manf and Xbp1 in Stroke

15 Jun 2022

Abstract excerpt

Stroke is a devastating medical condition with no treatment to hasten recovery. Its abrupt nature results in cataclysmic changes in the affected tissues. Resident cells fail to cope with the cellular stress resulting in massive cell death, which cannot be endogenously repaired. A potential strategy to improve stroke outcomes is to boost endogenous pro-survival pathways. The unfolded protein response (UPR), an...

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PMID: 35783104
DOI: 10.3389/fncel.2022.900725

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