Article

Precursor-dependent steroid conversion sustains androgen receptor signaling and lineage-state divergence in prostate cancer

2026-07-07

Abstract excerpt

<title>Abstract</title> <p> Castration-resistant prostate cancer (CRPC) persists despite systemic androgen deprivation, an adaptive mechanism frequently attributed to autonomous <italic>de novo</italic> intratumoral steroidogenesis. Despite the widespread clinical deployment of upstream inhibitors, the true structural and metabolic fidelity of the models underpinning this "tumor-as-gonad" dogma remains highly...

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Literature Corpus work: c1d16371-a700-5e54-97c1-e9eb1e0430f8
DOI: 10.21203/rs.3.rs-10247743/v1

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