Article

5β-Dihydrotestosterone reveals a mutant androgen receptor vulnerability in prostate cancer

2026-07-15

Abstract excerpt

Bipolar androgen therapy (BAT) exploits the paradoxical vulnerability of castration-resistant prostate cancer (CRPC) cells to rapid cycling between castrate and supraphysiologic androgen concentrations, but clinical BAT uses testosterone, which can also activate wild-type androgen receptor (AR) in androgen-responsive tissues, causing systemic side effects. 5β-dihydrotestosterone (5β-DHT) is a naturally occurring t...

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Literature Corpus work: f16d5ecf-882c-5dd4-ac37-ebc7d5a43b99
DOI: 10.64898/2026.07.14.738538

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