Article

Multi-Omics Profiling Exposes a Metabolic Void in Prostate Cancer Models That Drives Precursor Dependence and Clinical Progression

2026-04-10

Abstract excerpt

Castration-resistant prostate cancer (CRPC) survives androgen deprivation, a mechanism widely attributed to autonomous de novo steroidogenesis. Despite the clinical deployment of CYP17A1 inhibitors, the metabolic fidelity of the models underpinning this "tumor-as-gonad" dogma remains controversial. Here, integrating high-resolution liquid chromatography-mass spectrometry with transcriptomics across diverse prostat...

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Literature Corpus work: ecde356f-78bb-5201-bdd7-4af8b390a44f
DOI: 10.20944/preprints202604.0750.v1

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