Article

Integrated metabolic and transcriptomic landscapes reveal an obligate reliance on exogenous steroid conversion for prostate cancer survival

2026-04-10

Abstract excerpt

<title>Abstract</title> <p>Castration-resistant prostate cancer (CRPC) survives androgen deprivation, a mechanism widely attributed to autonomous de novo steroidogenesis. Despite the clinical deployment of CYP17A1 inhibitors, the metabolic fidelity of the models underpinning this "tumor-as-gonad" dogma remains controversial. Here, integrating high-resolution liquid chromatography-mass spectrometry with transcript...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6b6399be-8bc4-5ab3-8f29-2b9e407bcb82
DOI: 10.21203/rs.3.rs-9358922/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated metabolic and transcriptomic landscapes reveal an obligate reliance on exogenous steroid conversion for prostate cancer survivalDOI 10.21203/rs.3.rs-9358922/v1Read

Multi-Omics Profiling Exposes a Metabolic Void in Prostate Cancer Models That Drives Precursor Dependence and Clinical ProgressionSemantic proximity Read

Precursor-dependent steroid conversion sustains androgen receptor signaling and lineage-state divergence in prostate cancerSemantic proximity Read

Single-cell analysis revealing the metabolic landscape of prostate cancerSemantic proximity Read

Subtype and Site Specific–Induced Metabolic Vulnerabilities in Prostate CancerSemantic proximity Read

Therapy-induced PSMA2 Sensitizes Prostate Cancer Cells to Residual Androgen and Promotes Neuroendocrine Lineage TransformationSemantic proximity Read

Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach.Semantic proximity Read

Prostate cancer castrate resistant progression usage of non-canonical androgen receptor signaling and ketone body fuelSemantic proximity Read

Distinct druggable biological processes in early-onset prostate cancerSemantic proximity Read

Loss of an Androgen-Inactivating and Isoform-Specific HSD17B4 Splice Form Enables Emergence of Castration-Resistant Prostate CancerSemantic proximity Read

Metabolic deregulation in prostate cancerSemantic proximity Read

Defining the combinatorial nature of gene modules in prostate cancer underlying lineage plasticity and metastasisSemantic proximity Read

MZF1-mediated GAPDH overexpression drives glycolytic reprogramming and neuroendocrine progression in advanced prostate cancerSemantic proximity Read