Article

Single-cell analysis reveals a kynurenine pathway enriched epithelial subpopulation and a HAAO/QA-FDPS metabolic axis in prostate cancer

2026-01-29

Abstract excerpt

<title>Abstract</title> <p>Emerging evidence highlights that metabolic reprogramming profoundly shapes the tumor microenvironment and immune evasion in prostate cancer. However, the functional role and mechanisms of tryptophan metabolism in prostate cancer progression remain unclear. Through single-cell transcriptomic analysis, we identified one tumor cell subtype characterized by high expression of 3-hydroxyanth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d4c2204e-03de-5bbd-aab3-8538f54f253f
DOI: 10.21203/rs.3.rs-8462205/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell analysis reveals a kynurenine pathway enriched epithelial subpopulation and a HAAO/QA-FDPS metabolic axis in prostate cancerDOI 10.21203/rs.3.rs-8462205/v1Read

Personalized Medicine for Prostate Cancer: Is Targeting Metabolism a Reality?Semantic proximity Read

Single-cell analysis revealing the metabolic landscape of prostate cancerSemantic proximity Read

The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It ComplicatedSemantic proximity Read

Integrated metabolic and transcriptomic landscapes reveal an obligate reliance on exogenous steroid conversion for prostate cancer survivalSemantic proximity Read

Metabolic CRISPR screening identifies RPE as a key regulator of acquired enzalutamide resistance through FKBP5 destabilization in prostate cancer.Semantic proximity Read

Metabolic Reprogramming and Predominance of Solute Carrier Genes during Acquired Enzalutamide Resistance in Prostate CancerSemantic proximity Read

DGAT1 as a Racially Divergent Driver of Carcinoma-Associated Fibroblast Activation Drives Tumorigenic Pathways via ERK1/2 Signaling in Prostate CancerSemantic proximity Read

Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosisSemantic proximity Read

Enzalutamide-induced signatures revealed by epigenetic plasticity using single-cell multi-omics sequencing in prostate cancerSemantic proximity Read

Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic ImplicationsSemantic proximity Read

A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulatorSemantic proximity Read

Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosisSemantic proximity Read